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Gyung Hyuck Ko 7 Articles
Xanthogranulomatous endometritis: a report of two Korean cases with cytologic findings
Ji Min Na, Min Hye Kim, Gyung Hyuck Ko, Jeong Kyu Shin
J Pathol Transl Med. 2020;54(6):513-516.   Published online October 23, 2020
DOI: https://doi.org/10.4132/jptm.2020.08.18
  • 2,584 View
  • 73 Download
  • 2 Web of Science
  • 2 Crossref
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  • Xanthogranulomatous endometritis
    A Morales Vicente, Y García Sánchez, N Santonja López, J Gilabert Estellés
    Facts, Views and Vision in ObGyn.2023; 15(4): 351.     CrossRef
  • Contrast-enhanced Ultrasound of Xanthogranulomatous Endometritis: A Case Report and Literature Review
    Hailan Wu, Juan Liu, Li Chen, Juan Peng
    Current Medical Imaging Formerly Current Medical Imaging Reviews.2023;[Epub]     CrossRef
Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
Hyun Min Koh, Hyo Jung An, Gyung Hyuck Ko, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Sung Hwan Kim, Kyung Nyeo Jeon, Gyeong-Won Lee, Se Min Jang, Dae Hyun Song
J Pathol Transl Med. 2019;53(1):13-22.   Published online November 26, 2018
DOI: https://doi.org/10.4132/jptm.2018.11.12
  • 6,679 View
  • 236 Download
  • 12 Web of Science
  • 10 Crossref
AbstractAbstract PDF
Background
S100A8 and S100A9 have been gaining recognition for modulating tumor growthand metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 innon-small cell lung cancer (NSCLC).
Methods
We analyzed the relationship between S100A8and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumorcells and peritumoral inflammatory cells.
Results
The positive staining of S100A8 in tumorcells was significantly increased in male (p < .001), smoker (p = .034), surgical method other thanlobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022)compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. Theproportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patientsex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patientage (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlatedwith patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumorcells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cellsstained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCCbut towards decreased survivability in ADC.
Conclusions
S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.

Citations

Citations to this article as recorded by  
  • Gene expression related to lung cancer altered by PHMG-p treatment in PBTE cells
    Yoon Hee Park, Sang Hoon Jeong, Hyejin Lee, Cherry Kim, Yoon Jeong Nam, Ja Young Kang, Jin Young Choi, Yu-Seon Lee, Su A. Park, Jaeyoung Kim, Eun-Kee Park, Yong-Wook Baek, Hong Lee, Ju-Han Lee
    Molecular & Cellular Toxicology.2023; 19(1): 205.     CrossRef
  • Discovery of protein biomarkers for venous thromboembolism in non-small cell lung cancer patients through data-independent acquisition mass spectrometry
    Yanhong Liu, Lan Gao, Yanru Fan, Rufei Ma, Yunxia An, Guanghui Chen, Yan Xie
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • S100A8 and S100A9 in Cancer
    Yu Chen, Yuzhen Ouyang, Zhixin Li, Xiufang Wang, Jian Ma
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2023; 1878(3): 188891.     CrossRef
  • Gene expression of S100a8/a9 predicts Staphylococcus aureus-induced septic arthritis in mice
    Meghshree Deshmukh, Santhilal Subhash, Zhicheng Hu, Majd Mohammad, Anders Jarneborn, Rille Pullerits, Tao Jin, Pradeep Kumar Kopparapu
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Single-cell immunophenotyping revealed the association of CD4+ central and CD4+ effector memory T cells linking exacerbating chronic obstructive pulmonary disease and NSCLC
    Nikolett Gémes, József Á. Balog, Patrícia Neuperger, Erzsébet Schlegl, Imre Barta, János Fillinger, Balázs Antus, Ágnes Zvara, Zoltán Hegedűs, Zsolt Czimmerer, Máté Manczinger, Gergő Mihály Balogh, József Tóvári, László G. Puskás, Gábor J. Szebeni
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • A Prognostic Gene Signature for Hepatocellular Carcinoma
    Rong Chen, Meng Zhao, Yanli An, Dongfang Liu, Qiusha Tang, Gaojun Teng
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • The S100 protein family in lung cancer
    Ting Wang, Ge Du, Dong Wang
    Clinica Chimica Acta.2021; 520: 67.     CrossRef
  • The associations of serum S100A9 with the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study
    Hong-Yan Liu, Hui-Xian Xiang, Ying Xiang, Zheng Xu, Chun-Mei Feng, Jun Fei, Lin Fu, Hui Zhao
    BMC Infectious Diseases.2021;[Epub]     CrossRef
  • Saliva proteomic analysis reveals possible biomarkers of renal cell carcinoma
    Xiao Li Zhang, Zheng Zhi Wu, Yun Xu, Ji Guo Wang, Yong Qiang Wang, Mei Qun Cao, Chang Hao Wang
    Open Chemistry.2020; 18(1): 918.     CrossRef
  • Prognostic Role of S100A8 in Human Solid Cancers: A Systematic Review and Validation
    An Huang, Wei Fan, Jiacui Liu, Ben Huang, Qingyuan Cheng, Ping Wang, Yiping Duan, Tiantian Ma, Liangyue Chen, Yanping Wang, Mingxia Yu
    Frontiers in Oncology.2020;[Epub]     CrossRef
Myoferlin Expression and Its Correlation with FIGO Histologic Grading in Early-Stage Endometrioid Carcinoma
Min Hye Kim, Dae Hyun Song, Gyung Hyuck Ko, Jeong Hee Lee, Dong Chul Kim, Jung Wook Yang, Hyang Im Lee, Hyo Jung An, Jong Sil Lee
J Pathol Transl Med. 2018;52(2):93-97.   Published online March 14, 2018
DOI: https://doi.org/10.4132/jptm.2017.11.29
  • 5,947 View
  • 114 Download
  • 10 Web of Science
  • 8 Crossref
AbstractAbstract PDF
Background
For endometrioid carcinoma patients, International Federation of Gynecologists and Obstetricians (FIGO) histologic grading is very important for identifying the appropriate treatment method. However, the interobserver discrepancy with this three-tiered grading system is a serious potential problem. In this study, we used immunohistochemistry to analyze the relationship between FIGO histologic grading score and myoferlin expression.
Methods
We studied the endometrioid carcinoma tissues of 60 patients from Gyeongsang National University Hospital between January 2002 and December 2009. Immunohistochemical analysis of myoferlin was performed on tissue microarray blocks from surgical specimens.
Results
Myoferlin expression was observed in 58 of 60 patients. Moderate and strong myoferlin expression was observed in low-grade endometrioid carcinoma, while there was a tendency toward loss of myoferlin expression in high-grade endometrioid carcinoma (p<.001).
Conclusions
Our study revealed that myoferlin loss is significantly correlated with high FIGO grade of endometrioid carcinoma.

Citations

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  • Neoexpression of JUNO in Oral Tumors Is Accompanied with the Complete Suppression of Four Other Genes and Suggests the Application of New Biomarker Tools
    Dominik Kraus, Simone Weider, Rainer Probstmeier, Jochen Winter
    Journal of Personalized Medicine.2022; 12(3): 494.     CrossRef
  • Correlation between myoferlin expression and lymph node metastasis in papillary thyroid carcinoma
    Ji Min Na, Dong Chul Kim, Dae Hyun Song, Hyo Jung An, Hyun Min Koh, Jeong-Hee Lee, Jong Sil Lee, Jung Wook Yang, Min Hye Kim
    Journal of Pathology and Translational Medicine.2022; 56(4): 199.     CrossRef
  • PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis
    Tao Qian, Chengmin Liu, Yanyan Ding, Chen Guo, Renwei Cai, Xiaoxia Wang, Rong Wang, Kuo Zhang, Li Zhou, Yi Deng, Chuanyue Wu, Ying Sun
    Oncogene.2020; 39(10): 2069.     CrossRef
  • Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
    Gilles Rademaker, Brunella Costanza, Justine Bellier, Michael Herfs, Raphaël Peiffer, Ferman Agirman, Naïma Maloujahmoum, Yvette Habraken, Philippe Delvenne, Akeila Bellahcène, Vincent Castronovo, Olivier Peulen
    Oncogenesis.2019;[Epub]     CrossRef
  • Prognostic significance of immunohistochemical staining for myoferlin in clear cell renal cell carcinoma and its association with epidermal growth factor receptor expression
    Minsun Jung, Cheol Lee, Jeong Hwan Park, Kyung Chul Moon
    Urologic Oncology: Seminars and Original Investigations.2019; 37(11): 812.e9.     CrossRef
  • Ferlin Overview: From Membrane to Cancer Biology
    Peulen, Rademaker, Anania, Turtoi, Bellahcène, Castronovo
    Cells.2019; 8(9): 954.     CrossRef
  • Myoferlin, a multifunctional protein in normal cells, has novel and key roles in various cancers
    Wei Zhu, Bolun Zhou, Chenxuan Zhao, Zhengqing Ba, Hongjuan Xu, Xuejun Yan, Weidong Liu, Bin Zhu, Lei Wang, Caiping Ren
    Journal of Cellular and Molecular Medicine.2019; 23(11): 7180.     CrossRef
  • Myoferlin, a Membrane Protein with Emerging Oncogenic Roles
    Yimin Dong, Honglei Kang, Huiyong Liu, Jia Wang, Qian Guo, Chao Song, Yunlong Sun, Ya Zhang, Honghua Zhang, Zheng Zhang, Hanfeng Guan, Zhong Fang, Feng Li
    BioMed Research International.2019; 2019: 1.     CrossRef
Programmed Death-Ligand 1 Expression and Its Correlation with Lymph Node Metastasis in Papillary Thyroid Carcinoma
Hyo Jung An, Gyung Hyuck Ko, Jeong-Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Jin Pyeong Kim, Eun Jung Jung, Dae Hyun Song
J Pathol Transl Med. 2018;52(1):9-13.   Published online October 3, 2017
DOI: https://doi.org/10.4132/jptm.2017.07.26
  • 8,181 View
  • 274 Download
  • 16 Web of Science
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AbstractAbstract PDF
Background
The immunotherapeutic role of programmed death-ligand 1 (PD-L1) in life expectancy in many cancers has been highlighted. However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited. In this study, we describe the PD-L1 and programmed cell death protein 1 (PD-1) expressions in PTC and analyze their correlation with lymph node (LN) metastasis.
Methods
Clinicopathological data were obtained from 116 patients with PTC who were treated in Gyeongsang National University Hospital, Jinju, Korea in 2009. Tissue microarray blocks were made using representative paraffin blocks of classical PTCs excluding follicular variants. Two pathologists graded the proportion and intensity of PD-L1 and PD-1 expression in both tumor and inflammatory cells. According to their proportions, positive PTC cells were scored as negative (0%), grade 1 (1%–50%), and grade 2 (51%–100%). Similarly, positive inflammatory cells were graded as negative (0%), grade 1 (1%–10%), and grade 2 (11%–20%). The intensity of each protein expression was simplified as positive or negative.
Results
A statistically significant correlation exists between the proportions of PD-1 and PD-L1 expression both in papillary carcinoma (p=.001) and peritumoral lymphoid cells in the thyroid (p<.001). In addition, the proportion of PD-L1 expression in PTC cells was closely related to metastatic LNs (p=.036).
Conclusions
PD-L1 is a valuable predictive marker for LN metastasis in PTC. Immunomodulating therapies that inhibit PD-L1 might be an option for patients with LN metastasis.

Citations

Citations to this article as recorded by  
  • Chronic Lymphocytic Thyroiditis with Oncocytic Metaplasia Influences PD-L1 Expression in Papillary Thyroid Carcinoma
    Vitor Barreto Santana, Vitória Machado Krüger, Maria Cristina Yunes Abrahão, Pietru Lentz Martins Cantú, Rosicler Luzia Brackmann, Gisele Moroni Pandolfi, Liane Scheffler Marisco, Gabriela Remonatto, Luciana Adolfo Ferreira, Marcia Silveira Graudenz
    Head and Neck Pathology.2024;[Epub]     CrossRef
  • Update regarding the role of PD-L1 in oncocytic thyroid lesions on cytological samples
    Marco Dell'Aquila, Pietro Tralongo, Alessia Granitto, Maurizio Martini, Sara Capodimonti, Mariangela Curatolo, Vincenzo Fiorentino, Alfredo Pontecorvi, Guido Fadda, Celestino Pio Lombardi, Maco Raffaelli, Liron Pantanowitz, Luigi Maria Larocca, Esther Dia
    Journal of Clinical Pathology.2023; 76(10): 671.     CrossRef
  • Analysis of anti‐apoptotic PVT1 oncogene and apoptosis‐related proteins (p53, Bcl2, PD‐1, and PD‐L1) expression in thyroid carcinoma
    Afaf T. Ibrahiem, Amin K. Makhdoom, Khalid S. Alanazi, Abdulaziz M. Alanazi, Abdulaziz M. Mukhlef, Saad H. Elshafey, Eman A. Toraih, Manal S. Fawzy
    Journal of Clinical Laboratory Analysis.2022;[Epub]     CrossRef
  • EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma
    Wenyue Zhao, Lu Liu, Xuehao Li, Shun Xu
    International Immunopharmacology.2022; 110: 109031.     CrossRef
  • Hashimoto’s Thyroiditis Minimizes Lymph Node Metastasis in BRAF Mutant Papillary Thyroid Carcinomas
    Peter P. Issa, Mahmoud Omar, Yusef Buti, Chad P. Issa, Bert Chabot, Christopher J. Carnabatu, Ruhul Munshi, Mohammad Hussein, Mohamed Aboueisha, Mohamed Shama, Ralph L. Corsetti, Eman Toraih, Emad Kandil
    Biomedicines.2022; 10(8): 2051.     CrossRef
  • Expression of β-Catenin in Thyroid Neoplasms (Histopathological and Immunohistochemical Study)
    Mohamed Sherif Ismail, Amr Mousa Abdel Gawad Mousa, Mohammed Faisal Darwish, M. Mostafa Salem, Randa Said
    Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 1565.     CrossRef
  • Identification and validation of an immune-related prognostic signature and key gene in papillary thyroid carcinoma
    Rujia Qin, Chunyan Li, Xuemin Wang, Zhaoming Zhong, Chuanzheng Sun
    Cancer Cell International.2021;[Epub]     CrossRef
  • PD‐L1 and thyroid cytology: A possible diagnostic and prognostic marker
    Marco Dell’Aquila, Alessia Granitto, Maurizio Martini, Sara Capodimonti, Alessandra Cocomazzi, Teresa Musarra, Vincenzo Fiorentino, Alfredo Pontecorvi, Celestino Pio Lombardi, Guido Fadda, Liron Pantanowitz, Luigi Maria Larocca, Esther Diana Rossi
    Cancer Cytopathology.2020; 128(3): 177.     CrossRef
  • Programmed Death-Ligand 1 (PD-L1) Is a Potential Biomarker of Disease-Free Survival in Papillary Thyroid Carcinoma: a Systematic Review and Meta-Analysis of PD-L1 Immunoexpression in Follicular Epithelial Derived Thyroid Carcinoma
    Ilaria Girolami, Liron Pantanowitz, Ozgur Mete, Matteo Brunelli, Stefano Marletta, Chiara Colato, Pierpaolo Trimboli, Anna Crescenzi, Massimo Bongiovanni, Mattia Barbareschi, Albino Eccher
    Endocrine Pathology.2020; 31(3): 291.     CrossRef
  • Regression of Papillary Thyroid Cancer during Nivolumab for Renal Cell Cancer
    Andrea Palermo, Andrea Napolitano, Daria Maggi, Anda Mihaela Naciu, Gaia Tabacco, Silvia Manfrini, Anna Crescenzi, Chiara Taffon, Francesco Pantano, Bruno Vincenzi, Guiseppe Tonini, Daniele Santini
    European Thyroid Journal.2020; 9(3): 157.     CrossRef
  • A potential biomarker hsa-miR-200a-5p distinguishing between benign thyroid tumors with papillary hyperplasia and papillary thyroid carcinoma
    Xian Wang, Shan Huang, Xiaocan Li, Dongrui Jiang, Hongzhen Yu, Qiang Wu, Chaobing Gao, Zhengsheng Wu, Yi-Hsien Hsieh
    PLOS ONE.2018; 13(7): e0200290.     CrossRef
  • Papillary Thyroid Carcinoma Emerging from Hashimoto Thyroiditis Demonstrates Increased PD-L1 Expression, Which Persists with Metastasis
    Daniel Lubin, Ezra Baraban, Amanda Lisby, Sahar Jalali-Farahani, Paul Zhang, Virginia Livolsi
    Endocrine Pathology.2018; 29(4): 317.     CrossRef
  • Chemotherapeutic Treatments Increase PD-L1 Expression in Esophageal Squamous Cell Carcinoma through EGFR/ERK Activation
    Hoi Yan Ng, Jian Li, Lihua Tao, Alfred King-Yin Lam, Kwok Wah Chan, Josephine Mun Yee Ko, Valen Zhuoyou Yu, Michael Wong, Benjamin Li, Maria Li Lung
    Translational Oncology.2018; 11(6): 1323.     CrossRef
Thymoma and Synchronous Primary Mediastinal Seminomas with Florid Follicular Lymphoid Hyperplasia in the Anterior Mediastinum: A Case Report and Review of the Literature
Hyang-im Lee, In-seok Jang, Kyung Nyeo Jeon, Gyung Hyuck Ko, Jong Sil Lee, Dong Chul Kim, Dae Hyun Song, Jeong-Hee Lee
J Pathol Transl Med. 2017;51(2):165-170.   Published online February 2, 2017
DOI: https://doi.org/10.4132/jptm.2016.08.24
  • 8,602 View
  • 136 Download
  • 6 Web of Science
  • 4 Crossref
AbstractAbstract PDF
Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular seminoma except for site-associated morphological features such as lymphoid follicular hyperplasia. Therefore, excluding metastasis is very important. Recently, we treated a young adult patient with multiple thymic masses that occurred simultaneously. The patient underwent a thymectomy for the removal of the mediastinal masses, one of which was diagnosed as type B2 invasive thymoma, and two of which were diagnosed as primary mediastinal seminomas with massive follicular hyperplasia. The patient received adjuvant chemotherapy after surgical resection. To our knowledge, this is the first description of a thymoma and a mediastinal seminoma occurring simultaneously in the thymus. We present this case along with a literature review.

Citations

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  • Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges
    Alexander Fichtner, Alexander Marx, Philipp Ströbel, Felix Bremmer
    Histopathology.2024; 84(1): 216.     CrossRef
  • Combined Thymic Epithelial Neoplasms – a Review
    Annikka Weissferdt
    International Journal of Surgical Pathology.2023; 31(6): 917.     CrossRef
  • Primary mediastinal seminoma presenting with paraneoplastic anti-Hu encephalitis: a case report and literature review
    Chelsey M. Williams, Derek B. Allison, Adam B. Coleman, Roshmita Bardhan, Jordan D. Miller, Zin W. Myint
    Frontiers in Oncology.2023;[Epub]     CrossRef
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    Charlotte Holmes, Peh Sun Loo, Sion Barnard
    Diagnostic Pathology.2021;[Epub]     CrossRef
Dedifferentiated Solitary Fibrous Tumor of Thoracic Cavity
Jung Wook Yang, Dae Hyun Song, In Seok Jang, Gyung Hyuck Ko
Korean J Pathol. 2014;48(3):250-253.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.250
  • 6,802 View
  • 63 Download
  • 5 Crossref
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Citations

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  • A case of slow-growing dedifferentiated solitary fibrous tumor of the pleura over a 7-year period
    Madoka Goto, Rio Takada, Yasuhisa Ichikawa, Hideki Tsubouchi, Yuta Kawasumi, Shoichi Mori
    The Journal of the Japanese Association for Chest Surgery.2022; 36(7): 821.     CrossRef
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    Javier Martin-Broto, Jose L. Mondaza-Hernandez, David S. Moura, Nadia Hindi
    Cancers.2021; 13(12): 2913.     CrossRef
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    Masashi Nishimura, Shinichiro Ota, Sumitaka Yamanaka, Kanako Shinada, Masaharu Shinkai
    Respirology Case Reports.2021;[Epub]     CrossRef
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    Hyung Kyu Park, Dan Bi Yu, Minjung Sung, Ensel Oh, Mingi Kim, Ji-Young Song, Mi-Sook Lee, Kyungsoo Jung, Ka-Won Noh, Sungbin An, Kyoung Song, Do-Hyun Nam, Yu Jin Kim, Yoon-La Choi
    Journal of Molecular Medicine.2019; 97(10): 1413.     CrossRef
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    Ji Hye Park, Eun Jeong Kim, O Kyu Noh, Hyun Ju Jung, Jun Eun Park
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Osteoclast-like Giant Cell Tumor of Parotid Gland with a Carcinomatous Component: A Case Report
Jung Wook Yang, Hyeon Cheol Kim, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Dae Hyun Song, Jin Pyeong Kim, Gyung Hyuck Ko
Korean J Pathol. 2012;46(3):297-301.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.297
  • 6,839 View
  • 56 Download
  • 5 Crossref
AbstractAbstract PDF

The giant cell tumor of the salivary gland is very rare, and 20 cases have been reported in the English-language literature. We report an additional case. A 57-year old man had noticed a mass in the right parotid area for several weeks. The diagnosis using aspiration cytology was a giant cell tumor possibly with a carcinomatous component. Superficial parotidectomy was carried out. The resected parotid gland contained a 1.8 cm-sized well-circumscribed brownish tumor. Histologically the tumor consisted of evenly distributed osteoclast-like giant cells, mononuclear cells and two small foci of a carcinomatous component. The osteoclast-like giant cells and mononuclear cells were positive for vimentin and CD68, and the carcinomatous component was positive for cytokeratin and epithelial membrane antigen. There was no metastatic lesion in the cervical lymph nodes. We believe this is the first case in Korea of an osteoclast-like giant cell tumor of the parotid gland.

Citations

Citations to this article as recorded by  
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    Pathology - Research and Practice.2021; 228: 153678.     CrossRef
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    S. Rammeh, I. Hergli, M.K. M’farrej, N. Znaidi, S. Nechi, R. Zermani
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